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Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis
During biliary disease, cholangiocytes become activated by various pathological stimuli, including transforming growth factorβ (TGFβ). The result is an epigenetically-regulated transcriptional program leading to a pro-fibrogenic microenvironment, activation of hepatic stellate cells (HSC), and progr...
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| Publicado no: | Hepatology |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6819212/ https://ncbi.nlm.nih.gov/pubmed/31070797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30706 |
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