Epigenomic Evaluation of Cholangiocyte TGFβ Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis

BACKGROUND & AIMS: Transforming growth factor β (TGFβ) upregulates cholangiocyte-derived signals that activate myofibroblasts and promote fibrosis. Using epigenomic and transcriptomic approaches, we sought to distinguish the epigenetic activation mechanisms downstream of TGFβ that mediate transc...

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Publicado en:Gastroenterology
Main Authors: Aseem, Sayed Obaidullah, Jalan-Sakrikar, Nidhi, Chi, Cheng, Navarro-Corcuera, Amaia, De Assuncao, Thiago M., Hamdan, Feda H., Chowdhury, Shiraj, Banales, Jesus M., Johnsen, Steven A., Shah, Vijay H., Huebert, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878301/
https://ncbi.nlm.nih.gov/pubmed/33058867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.10.008
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