Structure-Activity Relationship (SAR) and Preliminary Mode of Action Studies of 3-Substituted Benzylthioquinolinium Iodide as Anti-opportunistic Infection Agents

Por Bolden, Sidney, Zhu, Xue Y., Etukala, Jagan R, Boateng, Comfort, Mazu, Tryphon, Flores-Rozas, Hernan, Jacob, Melissa R., Khan, Shabana I, Walker, Larry A., Ablordeppey, Seth Y.
Publicado em 2013

2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase

Por Küçükgüzel, İlkay, Satilmiş, Gökhan, Gurukumar, K.R., Basu, Amartya, Tatar, Esra, Nichols, Daniel B., Talele, Tanaji T., Kaushik-Basu, Neerja
Publicado em 2013

Expanding Chemical Diversity of Conotoxins: Peptoid-Peptide Chimeras of the Sodium Channel Blocker µ-KIIIA and its Selenopeptide Analogues

Por Walewska, Aleksandra, Han, Tiffany S., Zhang, Min-Min, Yoshikami, Doju, Bulaj, Grzegorz, Rolka, Krzysztof
Publicado no Eur J Med Chem (2013)

Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors

Por Chenna, Bala Chandra, King, Jason R., Shinkre, Bidhan A., Glover, Amanda L., Lucius, Aaron L., Velu, Sadanandan E.
Publicado no Eur J Med Chem (2010)

Probes for narcotic receptor mediated phenomena 49. N-Substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols

Por Iyer, Malliga R., Rothman, Richard B., Dersch, Christina M., Jacobson, Arthur E., Rice, Kenner C.
Publicado no Eur J Med Chem (2015)

Structure-Based Inhibition of Protein-Protein Interactions

Por Watkins, Andrew M., Arora, Paramjit S.
Publicado no Eur J Med Chem (2014)

Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer’s disease

Por Vangavaragu, Jhansi Rani, Valasani, Koteswara Rao, Gan, Xueqi, Yan, Shirley ShiDu
Publicado no Eur J Med Chem (2014)

Metronidazole-triazole conjugates: Activity against Clostridium difficile and parasites

Por Jarrad, Angie M., Karoli, Tomislav, Debnath, Anjan, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A.T., Cooper, Matthew A.
Publicado no Eur J Med Chem (2015)

Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors

Por Yu, Le-Mao, Zhang, Xiao-Ru, Li, Xiao-Bing, Yang, Yuan, Wei, Hong-Yu, He, Xi-Xin, Gu, Lian-Quan, Huang, Zhi-Shu, Pommier, Yves, An, Lin-Kun
Publicado no Eur J Med Chem (2015)

Probing the Structural Requirements of Non-electrophilic Naphthalene-Based Nrf2 Activators

Por Jain, Atul D., Potteti, Haranatha, Richardson, Benjamin G., Kingsley, Laura, Luciano, Julia P., Ryuzoji, Aya F., Lee, Hyun, Krunic, Aleksej, Mesecar, Andrew D., Reddy, Sekhar P., Moore, Terry W.
Publicado no Eur J Med Chem (2015)

Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities

Por Bionda, Nina, Fleeman, Renee M., de la Fuente-Núñez, César, Rodriguez, Maria C., Reffuveille, Fany, Shaw, Lindsey N., Pastar, Irena, Davis, Stephen C., Hancock, Robert E. W., Cudic, Predrag
Publicado no Eur J Med Chem (2015)

A structural insight into the P1-S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases

Por Węglarz-Tomczak, Ewelina, Berlicki, Łukasz, Pawełczak, Małgorzata, Nocek, Bogusław, Joachimiak, Andrzej, Mucha, Artur
Publicado no Eur J Med Chem (2016)

Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds

Por Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Szular, Joanna, Kaiser, Marcel
Publicado no Eur J Med Chem (2016)

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective

Por Abadi, Ashraf H., Gary, Bernard D., Tinsley, Heather N., Piazza, Gary A., Abdel-Halim, Mohammad
Publicado no Eur J Med Chem (2010)

Synthesis and in Vitro Evaluation of New Analogues as Inhibitors for Phosphodiesterase 10A

Por Zhang, Zhanbin, Lu, Xiaoxia, Xu, Jinbin, Rothfuss, Justin, Mach, Robert H., Tu, Zhude
Publicado em 2011

One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent

Por Romagnoli, Romeo, Baraldi, Pier Giovanni, Cara, Carlota Lopez, Salvador, Maria Kimatrai, Bortolozzi, Roberta, Basso, Giuseppe, Viola, Giampietro, Balzarini, Jan, Brancale, Andrea, Fu, Xian-Hua, Li, Jun, Zhang, Su-Zhan, Hamel, Ernest
Publicado em 2011

Dendrimer-based Multivalent Methotrexates as Dual Acting Nanoconjugates for Cancer Cell Targeting

Por Li, Ming-Hsin, Choi, Seok Ki, Thomas, Thommey P., Desai, Ankur, Lee, Kyung-Hoon, Kotlyar, Alina, Banaszak Holl, Mark M., Baker, James R.
Publicado em 2011

Novel Triacsin C Analogs as Potential Antivirals against Rotavirus Infections

Por Kim, Yunjeong, George, David, Prior, Allan M., Prasain, Keshar, Hao, Shuanghong, Le, Duy D., Hua, Duy H., Chang, Kyeong-Ok
Publicado em 2012

Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis

Por Nammalwar, Baskar, Bunce, Richard A., Berlin, K. Darrell, Bourne, Christina R., Bourne, Philip C., Barrow, Esther W., Barrow, William W.
Publicado em 2012

Potent Direct Inhibitors of Factor Xa Based on the Tetrahydroisoquinoline Scaffold

Por Al-Horani, Rami A., Mehta, Akul Y., Desai, Umesh R.
Publicado em 2012