Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis

A series of substituted 2,4-diaminopyrimidines 1 has been prepared and evaluated for activity against Bacillus anthracis using previously reported (±)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-(1-propyl-2(1H)-phthalazinyl)-2-propen-1-one (1a), with a minimum inhibitory concentr...

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Detalhes bibliográficos
Main Authors: Nammalwar, Baskar, Bunce, Richard A., Berlin, K. Darrell, Bourne, Christina R., Bourne, Philip C., Barrow, Esther W., Barrow, William W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408765/
https://ncbi.nlm.nih.gov/pubmed/22703705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.05.018
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