Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis

The current paper describes the synthesis and biological evaluation of dihydrophthalazine-appended 2,4-diaminopyrimidine (DAP) inhibitors (1) oxidized at the methylene bridge linking the DAP ring to the central aromatic ring and (2) modified at the central ring ether groups. Structures 4a-b incorpor...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Nammalwar, Baskar, Bourne, Christina R., Wakeham, Nancy, Bourne, Philip C., Barrow, Esther W., Muddala, N. Prasad, Bunce, Richard A., Berlin, K. Darrell, Barrow, William W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278362/
https://ncbi.nlm.nih.gov/pubmed/25435253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.11.009
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