Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines

A series of (±)-6-alkyl-2,4-diaminopyrimidine-based inhibitors of bacterial dihydrofolate reductase (DHFR) have been prepared and evaluated for biological potency against Bacillus anthracis and Staphylococcus aureus. Biological studies reveal attenuated activity relative to earlier structures lackin...

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Detalhes bibliográficos
Main Authors: Nammalwar, Baskar, Bourne, Christina R., Bunce, Richard A., Wakeham, Nancy, Bourne, Philip C., Ramnarayan, Kal, Mylvaganam, Shankari, Berlin, K. Darrell, Barrow, Esther W., Barrow, William W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570588/
https://ncbi.nlm.nih.gov/pubmed/22930550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200291
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