Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines

A series of (±)-6-alkyl-2,4-diaminopyrimidine-based inhibitors of bacterial dihydrofolate reductase (DHFR) have been prepared and evaluated for biological potency against Bacillus anthracis and Staphylococcus aureus. Biological studies reveal attenuated activity relative to earlier structures lackin...

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Bibliografische gegevens
Hoofdauteurs: Nammalwar, Baskar, Bourne, Christina R., Bunce, Richard A., Wakeham, Nancy, Bourne, Philip C., Ramnarayan, Kal, Mylvaganam, Shankari, Berlin, K. Darrell, Barrow, Esther W., Barrow, William W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570588/
https://ncbi.nlm.nih.gov/pubmed/22930550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200291
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