Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines

A series of (±)-6-alkyl-2,4-diaminopyrimidine-based inhibitors of bacterial dihydrofolate reductase (DHFR) have been prepared and evaluated for biological potency against Bacillus anthracis and Staphylococcus aureus. Biological studies reveal attenuated activity relative to earlier structures lackin...

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Bibliografiske detaljer
Main Authors: Nammalwar, Baskar, Bourne, Christina R., Bunce, Richard A., Wakeham, Nancy, Bourne, Philip C., Ramnarayan, Kal, Mylvaganam, Shankari, Berlin, K. Darrell, Barrow, Esther W., Barrow, William W.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570588/
https://ncbi.nlm.nih.gov/pubmed/22930550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200291
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