The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking

[Image: see text] We are addressing bacterial resistance to antibiotics by repurposing a well-established classic antimicrobial target, the dihydrofolate reductase (DHFR) enzyme. In this work, we have focused on Enterococcus faecalis, a nosocomial pathogen that frequently harbors antibiotic resistan...

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Bibliographic Details
Main Authors: Bourne, Christina R., Wakeham, Nancy, Webb, Nicole, Nammalwar, Baskar, Bunce, Richard A., Berlin, K. Darrell, Barrow, William W.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985486/
https://ncbi.nlm.nih.gov/pubmed/24495113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401104t
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