Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase

Staphylococcus aureus (Sa) is a serious concern due to increasing resistance to antibiotics. The bacterial dihydrofolate reductase enzyme is effectively inhibited by trimethoprim, a compound with antibacterial activity. Previously, we reported a trimethoprim derivative containing an acryloyl linker...

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Pubblicato in:Eur J Med Chem
Autori principali: Muddala, N. Prasad, White, John C., Nammalwar, Baskar, Pratt, Ian, Thomas, Leonard M., Bunce, Richard A., Berlin, K. Darrell, Bourne, Christina R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7932028/
https://ncbi.nlm.nih.gov/pubmed/32502861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112412
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