Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1

The bacterial burden on human health is quickly outweighing available therapeutics. Our long-term goal is the development of antimicrobials with the potential for broad-spectrum activity. We previously reported phthalazine-based inhibitors of dihydrofolate reductase (DHFR) with potent activity again...

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Detalles Bibliográficos
Autores principales: Bourne, C. R., Barrow, E. W., Bunce, R. A., Bourne, P. C., Berlin, K. D., Barrow, W. W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Susceptibility
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934973/
https://ncbi.nlm.nih.gov/pubmed/20606069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00361-10
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