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Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase
Staphylococcus aureus (Sa) is a serious concern due to increasing resistance to antibiotics. The bacterial dihydrofolate reductase enzyme is effectively inhibited by trimethoprim, a compound with antibacterial activity. Previously, we reported a trimethoprim derivative containing an acryloyl linker...
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| 出版年: | Eur J Med Chem |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7932028/ https://ncbi.nlm.nih.gov/pubmed/32502861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112412 |
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