Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex

The synthesis and evaluation of ten new dihydrophthalazine-appended 2,4-diaminopyrimidines as potential drugs to treat Bacillus anthracis is reported. An improved synthesis utilizing a new pincer catalyst, dichlorobis[1-(dicyclohexylphosphanyl)-piperidine]palladium(II), allows the final Heck couplin...

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Pubblicato in:Molecules
Autori principali: Muddala, Nagendra Prasad, Nammalwar, Baskar, Selvaraju, Subhashini, Bourne, Christina R., Henry, Mary, Bunce, Richard A., Berlin, K. Darrell, Barrow, Esther W., Barrow, William W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445145/
https://ncbi.nlm.nih.gov/pubmed/25905602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20047222
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