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Potent Direct Inhibitors of Factor Xa Based on the Tetrahydroisoquinoline Scaffold
Direct inhibition of coagulation factor Xa (FXa) carries significant promise for developing effective and safe anticoagulants. Although a large number of FXa inhibitors have been studied, each can be classified as either possessing a highly flexible or a rigid core scaffold. We reasoned that an inte...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3408863/ https://ncbi.nlm.nih.gov/pubmed/22770607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.06.032 |
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