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Potent Direct Inhibitors of Factor Xa Based on the Tetrahydroisoquinoline Scaffold

Direct inhibition of coagulation factor Xa (FXa) carries significant promise for developing effective and safe anticoagulants. Although a large number of FXa inhibitors have been studied, each can be classified as either possessing a highly flexible or a rigid core scaffold. We reasoned that an inte...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Al-Horani, Rami A., Mehta, Akul Y., Desai, Umesh R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408863/
https://ncbi.nlm.nih.gov/pubmed/22770607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.06.032
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