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Designing Non-Saccharide, Allosteric Activators of Antithrombin for Accelerated Inhibition of Factor Xa
Antithrombin is a key regulator of coagulation and prime target of heparins, clinically used anticoagulants. Heparins induce a two-step conformational activation of antithrombin, a process that has remained challenging to target with molecules devoid of the antithrombin-binding pentasaccharide DEFGH...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165067/ https://ncbi.nlm.nih.gov/pubmed/21800826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2008387 |
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