טוען...
On Designing Non-Saccharide, Allosteric Activators of Antithrombin
Antithrombin, a plasma glycoprotein serpin, requires conformational activation by heparin to induce an anticoagulant effect, which is mediated through accelerated factor Xa inhibition. Heparin, a highly charged polymer and an allosteric activator of the serpin, is associated with major adverse effec...
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| Main Authors: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2008
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743457/ https://ncbi.nlm.nih.gov/pubmed/18996625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2008.09.042 |
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