Φορτώνει......
First Steps in the Direction of Synthetic, Allosteric, Direct Inhibitors of Thrombin and Factor Xa
Designing non-saccharide functional mimics of heparin is a major challenge. In this work, a library of small, aromatic molecules based on the sulfated DHP scaffold was synthesized and screened against thrombin and factor Xa. The results reveal that i) selected monomeric benzofuran derivatives inhibi...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714770/ https://ncbi.nlm.nih.gov/pubmed/19540113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.06.013 |
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