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First Steps in the Direction of Synthetic, Allosteric, Direct Inhibitors of Thrombin and Factor Xa
Designing non-saccharide functional mimics of heparin is a major challenge. In this work, a library of small, aromatic molecules based on the sulfated DHP scaffold was synthesized and screened against thrombin and factor Xa. The results reveal that i) selected monomeric benzofuran derivatives inhibi...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714770/ https://ncbi.nlm.nih.gov/pubmed/19540113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.06.013 |
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