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Rational Design of Potent, Small, Synthetic Allosteric Inhibitors of Thrombin
Thrombin is a key enzyme targeted by the majority of current anticoagulants that are direct inhibitors. Allosteric inhibition of thrombin may offer a major advantage of finely tuned regulation. We present here sulfated benzofurans as the first examples of potent, small allosteric inhibitors of throm...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3150610/ https://ncbi.nlm.nih.gov/pubmed/21714536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2005767 |
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