Rational Design of Potent, Small, Synthetic Allosteric Inhibitors of Thrombin

Eitemau Tebyg

• Designing Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Sub-Sites That Can Be Targeted By Sulfated Small Molecules for Inducing Inhibition
  gan: Sidhu, Preetpal Singh, et al.
  Cyhoeddwyd: (2013)
• First Steps in the Direction of Synthetic, Allosteric, Direct Inhibitors of Thrombin and Factor Xa
  gan: Verghese, Jenson, et al.
  Cyhoeddwyd: (2009)
• Designing Allosteric Regulators of Thrombin. Monosulfated Benzofuran Dimers Selectively Interact With Arg173 of Exosite II to Induce Inhibition
  gan: Abdel Aziz, May H., et al.
  Cyhoeddwyd: (2012)
• Sulfated, Low Molecular Weight Lignins are Potent Inhibitors of Plasmin, in Addition to Thrombin and Factor Xa : Novel Opportunity for Controlling Complex Pathologies
  gan: Henry, Brian L., et al.
  Cyhoeddwyd: (2009)
• Sulfated Pentagalloylglucoside is a Potent, Allosteric, and Selective Inhibitor of Factor XIa
  gan: Al-Horani, Rami A., et al.
  Cyhoeddwyd: (2013)