First Steps in the Direction of Synthetic, Allosteric, Direct Inhibitors of Thrombin and Factor Xa

Designing non-saccharide functional mimics of heparin is a major challenge. In this work, a library of small, aromatic molecules based on the sulfated DHP scaffold was synthesized and screened against thrombin and factor Xa. The results reveal that i) selected monomeric benzofuran derivatives inhibi...

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Hlavní autoři: Verghese, Jenson, Liang, Aiye, Sidhu, Preet Pal Singh, Hindle, Michael, Zhou, Qibing, Desai, Umesh R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714770/
https://ncbi.nlm.nih.gov/pubmed/19540113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.06.013
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