Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity

Por Chorell, Erik, Bengtsson, Christoffer, Banchelin, Thomas Sainte-Luce, Das, Pralay, Uvell, Hanna, Sinha, Arun K., Pinkner, Jerome S., Hultgren, Scott J., Almqvist, Fredrik
Publicado em 2011

Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases

Por Amblard, Franck, Fromentin, Emilie, Detorio, Mervi, Obikhod, Alexander, Rapp, Kimberly L., McBrayer, Tamara R., Whitaker, Tony, Coats, Steven J., Schinazi, Raymond F.
Publicado em 2009

Small lipidated anti-obesity compounds derived from neuromedin U

Por Micewicz, Ewa D., Bahattab, Omar S.O., Willars, Gary B., Waring, Alan J., Navab, Mohamad, Whitelegge, Julian P., McBride, William H., Ruchala, Piotr
Publicado no Eur J Med Chem (2015)

Evaluation of 2-Thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA Activators

Por Marugan, Juan J., Zheng, Wei, Motabar, Omid, Southall, Noel, Goldin, Ehud, Sidransky, Ellen, Aungst, Ronald A., Liu, Ke, Sadhukhan, Subir Kumar, Austin, Christopher P.
Publicado em 2010

Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors

Por Jarończyk, Małgorzata, Wołosewicz, Karol, Gabrielsen, Mari, Nowak, Gabriel, Kufareva, Irina, Mazurek, Aleksander P., Ravna, Aina W., Abagyan, Ruben, Bojarski, Andrzej J., Sylte, Ingebrigt, Chilmonczyk, Zdzisław
Publicado em 2012

Design, Synthesis and Biological Evaluation of Sulfur-Containing 1,1-Bisphosphonic Acids as Antiparasitic Agents

Por Recher, Marion, Barboza, Alejandro P., Li, Zhu-Hong, Galizzi, Melina, Ferrer-Casal, Mariana, Szajnman, Sergio H., Docampo, Roberto, Moreno, Silvia N. J., Rodriguez, Juan B.
Publicado em 2012

Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogues for boron neutron capture therapy of cancer

Por Agarwal, Hitesh K., Khalil, Ahmed, Ishita, Keisuke, Yang, Weilian, Nakkula, Robin J., Wu, Lai-Chu, Ali, Tehane, Tiwari, Rohit, Byun, Youngjoo, Barth, Rolf F., Tjarks, Werner
Publicado no Eur J Med Chem (2015)

New Highly Active Antiplatelet Agents with Dual Specificity for Platelet P2Y(1) and P2Y(12) Adenosine Diphosphate Receptors

Por Yanachkov, Ivan B., Chang, Hung, Yanachkova, Milka I., Dix, Edward J., Berny-Lang, Michelle A., Gremmel, Thomas, Michelson, Alan D., Wright, George E., Frelinger, Andrew L.
Publicado no Eur J Med Chem (2015)

Development of Potent and Selective Plasmodium falciparum Calcium-Dependent Protein Kinase 4 (PfCDPK4) Inhibitors that Block the Transmission of Malaria to Mosquitoes

Por Vidadala, Rama Subba Rao, Ojo, Kayode K., Johnson, Steven M., Zhang, Zhongsheng, Leonard, Stephen E., Mitra, Arinjay, Choi, Ryan, Reid, Molly C., Keyloun, Katelyn R., Fox, Anna M.W., Kennedy, Mark, Silver-Brace, Tiffany, Hume, Jen C. C., Kappe, Stefan, Verlinde, Christophe L.M.J., Fan, Erkang, Merritt, Ethan A., Van Voorhis, Wesley C., Maly, Dustin J.
Publicado em 2014

The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methy...

Por Pati, Hari N., Das, Umashankar, Das, Swagatika, Bandy, Brian, De Clercq, Erik, Balzarini, Jan, Kawase, Masami, Sakagami, Hiroshi, Quail, J. Wilson, Stables, James P., Dimmock, Jonathan R.
Publicado em 2008

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation

Por Soukarieh, Fadi, Nowicki, Matthew W., Bastide, Amandine, Pöyry, Tuija, Jones, Carolyn, Dudek, Kate, Patwardhan, Geetanjali, Meullenet, François, Oldham, Neil J., Walkinshaw, Malcolm D., Willis, Anne E., Fischer, Peter M.
Publicado no Eur J Med Chem (2016)

Optimization of Physicochemical Properties for 4-Anilinoquinazoline Inhibitors of Trypanosome Proliferation

Por Woodring, Jennifer L., Bachovchin, Kelly A., Brady, Kimberly G., Gallerstein, Mitchell F., Erath, Jessey, Tanghe, Scott, Leed, Susan E., Rodriguez, Ana, Mensa-Wilmot, Kojo, Sciotti, Richard J., Pollastri, Michael P.
Publicado no Eur J Med Chem (2017)

Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid

Por Hearn, Michael J., Cynamon, Michael H., Chen, Michaeline F., Coppins, Rebecca, Davis, Jessica, Kang, Helen Joo-On, Noble, Abigail, Tu-Sekine, Becky, Terrot, Marianne S., Trombino, Daniella, Thai, Minh, Webster, Eleanor R., Wilson, Rebecca
Publicado em 2009

Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3′-azido-2′,3′-dideoxypurine nucleosides

Por Zhang, Hong-wang, Detorio, Mervi, Herman, Brian D., Solomon, Sarah, Bassit, Leda, Nettles, James H., Obikhod, Aleksandr, Tao, Si-jia, Mellors, John W., Sluis-Cremer, Nicolas, Coats, Steven J., Schinazi, Raymond F.
Publicado em 2011

Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis

Por Baldwin, Patrick R., Reeves, Analise Z., Powell, Kimberly R., Napier, Ruth J., Swimm, Alyson I., Sun, Aiming, Giesler, Kyle, Bommarius, Bettina, Shinnick, Thomas M., Snyder, James P., Liotta, Dennis C., Kalman, Daniel
Publicado no Eur J Med Chem (2015)

PET radiotracer [(18)F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation

Por Perrone, Maria Grazia, Malerba, Paola, Uddin, Jashim, Vitale, Paola, Panella, Andrea, Crews, Brenda C., Daniel, Cristina K., Ghebreselasie, Kebreab, Nickels, Mike, Tantawy, Mohammed N., Manning, H. Charles, Marnett, Lawrence J., Scilimati, Antonio
Publicado no Eur J Med Chem (2014)

O-Alkylhydroxylamines as Rationally-designed Mechanism-based Inhibitors of Indoleamine 2,3-Dioxygenase-1

Por Malachowski, William P., Winters, Maria, DuHadaway, James B., Lewis-Ballester, Ariel, Badir, Shorouk, Wai, Jenny, Rahman, Maisha, Sheikh, Eesha, LaLonde, Judith M., Yeh, Syun-Ru, Prendergast, George C., Muller, Alexander J.
Publicado no Eur J Med Chem (2015)

Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)

Por Ramasubba Rao, Vidadala, Muthenna, Puppala, Shankaraiah, Gundeti, Akileshwari, Chandrasekhar, Hari Babu, Kothapalli, Suresh, Ganji, Suresh Babu, Katragadda, Chandra Kumar, Rotte Sateesh, Rajendra Prasad, Kothakonda, Ashok Yadav, Potharaju, Petrash, J. Mark, Bhanuprakash Reddy, Geereddy, Madhusudana Rao, Janaswamy
Publicado em 2012

Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II)

Por Jayatunga, Madura K. P., Thompson, Sam, McKee, Tawnya C., Chan, Mun Chiang, Reece, Kelie M., Hardy, Adam P., Sekirnik, Rok, Seden, Peter T., Cook, Kristina M., McMahon, James B., Figg, William D., Schofield, Christopher J., Hamilton, Andrew D.
Publicado no Eur J Med Chem (2014)

5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells()

Por Henry, Sean, Kidner, Ria, Reisenauer, Mary R., Magedov, Igor V., Kiss, Robert, Mathieu, Véronique, Lefranc, Florence, Dasari, Ramesh, Evidente, Antonio, Yu, Xiaojie, Ma, Xiuye, Pertsemlidis, Alexander, Cencic, Regina, Pelletier, Jerry, Cavazos, David A., Brenner, Andrew J., Aksenov, Alexander V., Rogelj, Snezna, Kornienko, Alexander, Frolova, Liliya V.
Publicado no Eur J Med Chem (2016)