Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)

As a continuation of our efforts directed towards the development of anti-diabetic agents from natural sources, piplartine was isolated from Piper chaba, and was found to inhibit recombinant human ALR2 with an IC50 of 160 µM. To improve the efficacy, a series of analogues have been synthesized by mo...

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Detalhes bibliográficos
Main Authors: Ramasubba Rao, Vidadala, Muthenna, Puppala, Shankaraiah, Gundeti, Akileshwari, Chandrasekhar, Hari Babu, Kothapalli, Suresh, Ganji, Suresh Babu, Katragadda, Chandra Kumar, Rotte Sateesh, Rajendra Prasad, Kothakonda, Ashok Yadav, Potharaju, Petrash, J. Mark, Bhanuprakash Reddy, Geereddy, Madhusudana Rao, Janaswamy
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857970/
https://ncbi.nlm.nih.gov/pubmed/23124161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.09.014
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