Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)

As a continuation of our efforts directed towards the development of anti-diabetic agents from natural sources, piplartine was isolated from Piper chaba, and was found to inhibit recombinant human ALR2 with an IC50 of 160 µM. To improve the efficacy, a series of analogues have been synthesized by mo...

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Detaylı Bibliyografya
Asıl Yazarlar: Ramasubba Rao, Vidadala, Muthenna, Puppala, Shankaraiah, Gundeti, Akileshwari, Chandrasekhar, Hari Babu, Kothapalli, Suresh, Ganji, Suresh Babu, Katragadda, Chandra Kumar, Rotte Sateesh, Rajendra Prasad, Kothakonda, Ashok Yadav, Potharaju, Petrash, J. Mark, Bhanuprakash Reddy, Geereddy, Madhusudana Rao, Janaswamy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857970/
https://ncbi.nlm.nih.gov/pubmed/23124161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.09.014
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