Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)

As a continuation of our efforts directed towards the development of anti-diabetic agents from natural sources, piplartine was isolated from Piper chaba, and was found to inhibit recombinant human ALR2 with an IC50 of 160 µM. To improve the efficacy, a series of analogues have been synthesized by mo...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Ramasubba Rao, Vidadala, Muthenna, Puppala, Shankaraiah, Gundeti, Akileshwari, Chandrasekhar, Hari Babu, Kothapalli, Suresh, Ganji, Suresh Babu, Katragadda, Chandra Kumar, Rotte Sateesh, Rajendra Prasad, Kothakonda, Ashok Yadav, Potharaju, Petrash, J. Mark, Bhanuprakash Reddy, Geereddy, Madhusudana Rao, Janaswamy
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857970/
https://ncbi.nlm.nih.gov/pubmed/23124161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.09.014
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars