Synthesis and biological evaluation of new piplartine analogues as potent aldose reductase inhibitors (ARIs)

As a continuation of our efforts directed towards the development of anti-diabetic agents from natural sources, piplartine was isolated from Piper chaba, and was found to inhibit recombinant human ALR2 with an IC50 of 160 µM. To improve the efficacy, a series of analogues have been synthesized by mo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ramasubba Rao, Vidadala, Muthenna, Puppala, Shankaraiah, Gundeti, Akileshwari, Chandrasekhar, Hari Babu, Kothapalli, Suresh, Ganji, Suresh Babu, Katragadda, Chandra Kumar, Rotte Sateesh, Rajendra Prasad, Kothakonda, Ashok Yadav, Potharaju, Petrash, J. Mark, Bhanuprakash Reddy, Geereddy, Madhusudana Rao, Janaswamy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857970/
https://ncbi.nlm.nih.gov/pubmed/23124161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.09.014
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