Preparation and antitubercular activities in vitro and in vivo of novel Schiff bases of isoniazid

Structural modification of the frontline antitubercular isonicotinic acid hydrazide (INH) provides lipophilic adaptations (3-46) of the drug in which the hydrazine moiety of the parent compound has been chemically blocked from the deactivating process of N(2)-acetylation by N-arylaminoacetyl transfe...

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Main Authors: Hearn, Michael J., Cynamon, Michael H., Chen, Michaeline F., Coppins, Rebecca, Davis, Jessica, Kang, Helen Joo-On, Noble, Abigail, Tu-Sekine, Becky, Terrot, Marianne S., Trombino, Daniella, Thai, Minh, Webster, Eleanor R., Wilson, Rebecca
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735020/
https://ncbi.nlm.nih.gov/pubmed/19524330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2009.05.009
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