Mycobacterium tuberculosis Dihydrofolate Reductase Is Not a Target Relevant to the Antitubercular Activity of Isoniazid

Mycobacterium tuberculosis enoyl-acyl-ACP reductase (InhA) has been demonstrated to be the primary target of isoniazid (INH). Recently, it was postulated that M. tuberculosis dihydrofolate reductase (DHFR) is also a target of INH, based on the findings that a 4R-INH-NADP adduct synthesized from INH...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Feng, Jain, Paras, Gulten, Gulcin, Liu, Zhen, Feng, Yicheng, Ganesula, Krishna, Motiwala, Alifiya S., Ioerger, Thomas R., Alland, David, Vilchèze, Catherine, Jacobs, William R., Sacchettini, James C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935018/
https://ncbi.nlm.nih.gov/pubmed/20566771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00453-10
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