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The Isoniazid Paradigm of Killing, Resistance, and Persistence in Mycobacterium tuberculosis
Isoniazid (INH) was the first synthesized drug that mediated bactericidal killing of the bacterium Mycobacterium tuberculosis, a major clinical breakthrough. To this day, INH remains a cornerstone of modern tuberculosis (TB) chemotherapy. This review describes the serendipitous discovery of INH, its...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6703971/ https://ncbi.nlm.nih.gov/pubmed/30797860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.02.016 |
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