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The Isoniazid Paradigm of Killing, Resistance, and Persistence in Mycobacterium tuberculosis

Isoniazid (INH) was the first synthesized drug that mediated bactericidal killing of the bacterium Mycobacterium tuberculosis, a major clinical breakthrough. To this day, INH remains a cornerstone of modern tuberculosis (TB) chemotherapy. This review describes the serendipitous discovery of INH, its...

詳細記述

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書誌詳細
出版年:J Mol Biol
主要な著者: Vilchèze, Catherine, Jacobs, William R.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703971/
https://ncbi.nlm.nih.gov/pubmed/30797860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.02.016
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