Altered NADH/NAD(+) Ratio Mediates Coresistance to Isoniazid and Ethionamide in Mycobacteria

The front-line antituberculosis drug isoniazid (INH) and the related drug ethionamide (ETH) are prodrugs that upon activation inhibit the synthesis of mycolic acids, leading to bactericidal activity. Coresistance to INH and ETH can be mediated by dominant mutations in the target gene inhA, encoding...

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Main Authors: Vilchèze, Catherine, Weisbrod, Torin R., Chen, Bing, Kremer, Laurent, Hazbón, Manzour H., Wang, Feng, Alland, David, Sacchettini, James C., Jacobs, William R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC547332/
https://ncbi.nlm.nih.gov/pubmed/15673755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.2.708-720.2005
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