NADH Dehydrogenase Defects Confer Isoniazid Resistance and Conditional Lethality in Mycobacterium smegmatis

Isoniazid (INH) is a highly effective drug used in the treatment and prophylaxis of Mycobacterium tuberculosis infections. Resistance to INH in clinical isolates has been correlated with mutations in the inhA, katG, and ahpC genes. In this report, we describe a new mechanism for INH resistance in My...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Miesel, Lynn, Weisbrod, Torin R., Marcinkeviciene, Jovita A., Bittman, Robert, Jacobs, William R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Physiology and Metabolism
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC107189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573199/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.180.9.2459-2467.1998
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