NADH Dehydrogenase Defects Confer Isoniazid Resistance and Conditional Lethality in Mycobacterium smegmatis

Isoniazid (INH) is a highly effective drug used in the treatment and prophylaxis of Mycobacterium tuberculosis infections. Resistance to INH in clinical isolates has been correlated with mutations in the inhA, katG, and ahpC genes. In this report, we describe a new mechanism for INH resistance in My...

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Publié dans:	J Bacteriol
Auteurs principaux:	Miesel, Lynn, Weisbrod, Torin R., Marcinkeviciene, Jovita A., Bittman, Robert, Jacobs, William R.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1998
Sujets:	Physiology and Metabolism
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC107189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573199/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.180.9.2459-2467.1998
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