NADH Dehydrogenase Defects Confer Isoniazid Resistance and Conditional Lethality in Mycobacterium smegmatis

Isoniazid (INH) is a highly effective drug used in the treatment and prophylaxis of Mycobacterium tuberculosis infections. Resistance to INH in clinical isolates has been correlated with mutations in the inhA, katG, and ahpC genes. In this report, we describe a new mechanism for INH resistance in My...

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書誌詳細

出版年:	J Bacteriol
主要な著者:	Miesel, Lynn, Weisbrod, Torin R., Marcinkeviciene, Jovita A., Bittman, Robert, Jacobs, William R.
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 1998
主題:	Physiology and Metabolism
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC107189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573199/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.180.9.2459-2467.1998
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