NADH Dehydrogenase Defects Confer Isoniazid Resistance and Conditional Lethality in Mycobacterium smegmatis

Isoniazid (INH) is a highly effective drug used in the treatment and prophylaxis of Mycobacterium tuberculosis infections. Resistance to INH in clinical isolates has been correlated with mutations in the inhA, katG, and ahpC genes. In this report, we describe a new mechanism for INH resistance in My...

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Dettagli Bibliografici

Pubblicato in:	J Bacteriol
Autori principali:	Miesel, Lynn, Weisbrod, Torin R., Marcinkeviciene, Jovita A., Bittman, Robert, Jacobs, William R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Physiology and Metabolism
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC107189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573199/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.180.9.2459-2467.1998
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