Altered NADH/NAD(+) Ratio Mediates Coresistance to Isoniazid and Ethionamide in Mycobacteria

The front-line antituberculosis drug isoniazid (INH) and the related drug ethionamide (ETH) are prodrugs that upon activation inhibit the synthesis of mycolic acids, leading to bactericidal activity. Coresistance to INH and ETH can be mediated by dominant mutations in the target gene inhA, encoding...

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Detaylı Bibliyografya
Asıl Yazarlar: Vilchèze, Catherine, Weisbrod, Torin R., Chen, Bing, Kremer, Laurent, Hazbón, Manzour H., Wang, Feng, Alland, David, Sacchettini, James C., Jacobs, William R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2005
Konular:
Mechanisms of Resistance
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC547332/
https://ncbi.nlm.nih.gov/pubmed/15673755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.2.708-720.2005
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