Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis

Spontaneous mutants of Mycobacterium tuberculosis that were resistant to the anti-tuberculosis drugs ethionamide and isoniazid were isolated and found to map to mshA, a gene encoding the first enzyme involved in the biosynthesis of mycothiol, a major low-molecular-weight thiol in M. tuberculosis. Se...

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Autors principals: Vilchèze, Catherine, Av-Gay, Yossef, Attarian, Rodgoun, Liu, Zhen, Hazbón, Manzour H, Colangeli, Roberto, Chen, Bing, Liu, Weijun, Alland, David, Sacchettini, James C, Jacobs, William R
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2008
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628429/
https://ncbi.nlm.nih.gov/pubmed/18651841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2008.06365.x
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