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Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase
[Image: see text] Homotetrameric R67 dihydrofolate reductase possesses 222 symmetry and a single active site pore. This situation results in a promiscuous binding site that accommodates either the substrate, dihydrofolate (DHF), or the cofactor, NADPH. NADPH interacts more directly with the protein...
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| Publicado no: | Biochemistry |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2015
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5147970/ https://ncbi.nlm.nih.gov/pubmed/26637016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00981 |
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