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Crowders Steal Dihydrofolate Reductase Ligands through Quinary Interactions
Dihydrofolate reductase (DHFR) reduces dihydrofolate (DHF) to tetrahydrofolate using NADPH as a cofactor. Due to its role in one carbon metabolism, chromosomal DHFR is the target of the antibacterial drug, trimethoprim. Resistance to trimethoprim has resulted in a type II DHFR that is not structural...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589827/ https://ncbi.nlm.nih.gov/pubmed/30724552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01110 |
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