Small Angle Neutron Scattering Studies of R67 Dihydrofolate Reductase, a Tetrameric Protein with Intrinsically Disordered N-Termini

[Image: see text] R67 dihydrofolate reductase (DHFR) is a homotetramer with a single active site pore and no sequence or structural homology with chromosomal DHFRs. The R67 enzyme provides resistance to trimethoprim, an active site-directed inhibitor of Escherichia coli DHFR. Sixteen to twenty N-ter...

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Publicat a:Biochemistry
Autors principals: Bhojane, Purva P., Duff, Michael R., Bafna, Khushboo, Agarwal, Pratul, Stanley, Christopher, Howell, Elizabeth E.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2017
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678894/
https://ncbi.nlm.nih.gov/pubmed/29020453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00822
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