Carregant...
Crowders Steal Dihydrofolate Reductase Ligands through Quinary Interactions
Dihydrofolate reductase (DHFR) reduces dihydrofolate (DHF) to tetrahydrofolate using NADPH as a cofactor. Due to its role in one carbon metabolism, chromosomal DHFR is the target of the antibacterial drug, trimethoprim. Resistance to trimethoprim has resulted in a type II DHFR that is not structural...
Guardat en:
| Publicat a: | Biochemistry |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6589827/ https://ncbi.nlm.nih.gov/pubmed/30724552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01110 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|