Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase

[Image: see text] Homotetrameric R67 dihydrofolate reductase possesses 222 symmetry and a single active site pore. This situation results in a promiscuous binding site that accommodates either the substrate, dihydrofolate (DHF), or the cofactor, NADPH. NADPH interacts more directly with the protein...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Duff, Michael R., Chopra, Shaileja, Strader, Michael Brad, Agarwal, Pratul K., Howell, Elizabeth E.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147970/
https://ncbi.nlm.nih.gov/pubmed/26637016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00981
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