Discovery of Potent Anticancer Agent HJC0416, an Orally Bioavailable Small Molecule Inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3)

Por Chen, Haijun, Yang, Zhengduo, Ding, Chunyong, Xiong, Ailian, Wild, Christopher, Wang, Lili, Ye, Na, Cai, Guoshuai, Flores, Rudolfo M., Ding, Ye, Shen, Qiang, Zhou, Jia
Publicado em 2014

Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

Por He, Guijia, Dou, Dengfeng, Wei, Liuqing, Alliston, Kevin R., Groutas, William C.
Publicado em 2010

Cyclosulfamide-based Derivatives as Inhibitors of Noroviruses

Por Dou, Dengfeng, Mandadapu, Sivakoteswara R., Alliston, Kevin R., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.
Publicado em 2011

In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways

Por Garsi, Jean-Baptiste, Sernissi, Lorenzo, Vece, Vito, Hanessian, Stephen, McCracken, Alison N., Simitian, Grigor, Edinger, Aimee L.
Publicado no Eur J Med Chem (2018)

Acyclic Nucleoside Bisphosphonates: Synthesis and Properties of Chiral 2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines

Por Doláková, Petra, Dračínský, Martin, Masojídková, Milena, Šolínová, Veronika, Kašička, Václav, Holý, Antonín
Publicado em 2008

Conformationally Constrained Analogues of N'-(4-t-Butylbenzyl)-N-(4-Methylsulfonylaminobenzyl)Thiourea as TRPV1 Antagonists

Por Ryu, HyungChul, Lim, Ju-Ok, Kang, Dong Wook, Pearce, Larry V., Tran, Richard, Toth, Attila, Lee, Jeewoo, Blumberg, Peter M.
Publicado em 2008

Opioid Bifunctional Ligands from Morphine and the Opioid Pharmacophore Dmt-Tic

Por Balboni, Gianfranco, Salvadori, Severo, Marczak, Ewa D., Knapp, Brian I., Bidlack, Jean M., Lazarus, Lawrence H., Peng, Xuemei, Si, Yu Gui, Neumeyer, John L.
Publicado em 2010

Synthesis and study of 2-amino- 7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds

Por Kálai, Tamás, Petrlova, Jitka, Balog, Mária, Aung, Hnin Hnin, Voss, John C., Hideg, Kálmán
Publicado em 2011

Cytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones and studies on their mechanisms of action

Por Andreani, Aldo, Granaiola, Massimiliano, Locatelli, Alessandra, Morigi, Rita, Rambaldi, Mirella, Varoli, Lucilla, Sega, Francesco Vieceli Dalla, Prata, Cecilia, Nguyen, Tam L., Bai, Ruoli, Hamel, Ernest
Publicado em 2013

Identification of two novel RET kinase inhibitors through MCR-based drug discovery: Design, synthesis and evaluation

Por Frett, Brendan, Moccia, Marialuisa, Carlomagno, Francesca, Santoro, Massimo, Li, Hong-yu
Publicado no Eur J Med Chem (2014)

Biphenylthiazole Antibiotics with an Oxadiazole Linker: An Approach to Improve Physicochemical Properties and Oral Bioavailability

Por Hagras, Mohamed, Hegazy, Youssef A., Elkabbany, Amr H., Mohammad, Haroon, Ghiaty, Adel, Abdelghany, Tamer M., Seleem, Mohamed N., Mayhoub, Abdelrahman S.
Publicado no Eur J Med Chem (2017)

New Insights into Structure–Activity Relationship of Ipomoeassin F from Its Bioisosteric 5-Oxa/Aza Analogues

Por Zong, Guanghui, Sun, Xianwei, Bhakta, Rima, Whisenhunt, Lucas, Hu, Zhijian, Wang, Feng, Shi, Wei Q.
Publicado no Eur J Med Chem (2017)

2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: Synthesis, antiproliferative activity, and mechanism of action

Por Raffa, Demetrio, Maggio, Benedetta, Raimondi, Maria Valeria, Cusimano, Maria Grazia, Giandomenico, Amico, Carollo, Anna, Conaldi, Pier Giulio, Bai, Ruoli, Hamel, Ernest, Daidone, Giuseppe
Publicado em 2013

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

Por Charton, Julie, Gauriot, Marion, Guo, Qing, Hennuyer, Nathalie, Marechal, Xavier, Dumont, Julie, Hamdane, Malika, Pottiez, Virginie, Landry, Valerie, Sperandio, Olivier, Flipo, Marion, Buee, Luc, Staels, Bart, Leroux, Florence, Tang, Wei-Jen, Deprez, Benoit, Deprez-Poulain, Rebecca
Publicado em 2014

Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors

Por Frett, Brendan, McConnell, Nick, Smith, Catherine C., Wang, Yuanxiang, Shah, Neil P., Li, Hong-yu
Publicado no Eur J Med Chem (2015)

Discovery and Characterization of Aryl Isonitriles as A New Class of Compounds versus Methicillin- and Vancomycin-resistant Staphylococcus aureus

Por Davis, Dexter C., Mohammad, Haroon, Kyei-Baffour, Kwaku, Younis, Waleed, Creemer, Cassidy Noel, Seleem, Mohamed N., Dai, Mingji
Publicado no Eur J Med Chem (2015)

Design, Synthesis, and Evaluation of a Novel Series of Macrocyclic Inhibitors of Norovirus 3CL Protease

Por Damalanka, Vishnu C., Kim, Yunjeong, Galasiti Kankanamalage, Anushka C., Lushington, Gerald H., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.
Publicado no Eur J Med Chem (2016)

Synthesis of 7-Benzylguanosine Cap Analogue Conjugates for eIF4E Targeted Degradation

Por Kaur, Tanpreet, Menon, Arya, Garner, Amanda L.
Publicado no Eur J Med Chem (2019)

Design, Synthesis, and X-Ray Studies of Potent HIV-1 Protease Inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.

Por Ghosh, Arun K., Jadhav, Ravindra D., Simpson, Hannah, Kovela, Satish, Osswald, Heather, Agniswamy, Johnson, Wang, Yuan-Fang, Hattori, Shin-ichiro, Weber, Irene T., Mitsuya, Hiroaki
Publicado no Eur J Med Chem (2018)

Recent Methodologies toward the Synthesis of Valdecoxib: A Potential 3,4-diarylisoxazolyl COX-2 Inhibitor

Por Dadiboyena, Sureshbabu, Nefzi, Adel
Publicado em 2010