Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors

The FLT3 kinase represents an attractive target to effectively treat AML. Unfortunately, no FLT3 targeted therapeutic is currently approved. In line with our continued interests in treating kinase related disease for anti-FLT3 mutant activity, we utilized pioneering synthetic methodology in combinat...

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Publicado en:Eur J Med Chem
Autores principales: Frett, Brendan, McConnell, Nick, Smith, Catherine C., Wang, Yuanxiang, Shah, Neil P., Li, Hong-yu
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666306/
https://ncbi.nlm.nih.gov/pubmed/25765758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.02.052
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