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Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors

The FLT3 kinase represents an attractive target to effectively treat AML. Unfortunately, no FLT3 targeted therapeutic is currently approved. In line with our continued interests in treating kinase related disease for anti-FLT3 mutant activity, we utilized pioneering synthetic methodology in combinat...

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Podrobná bibliografie
Vydáno v:Eur J Med Chem
Hlavní autoři: Frett, Brendan, McConnell, Nick, Smith, Catherine C., Wang, Yuanxiang, Shah, Neil P., Li, Hong-yu
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666306/
https://ncbi.nlm.nih.gov/pubmed/25765758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.02.052
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