Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT

FMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML. A frequent, clinical limitation is FLT3 selectivity, as concomitant inhibition...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bharate, Jaideep B., McConnell, Nicholas, Naresh, Gunaganti, Zhang, Lingtian, Lakkaniga, Naga Rajiv, Ding, Lucky, Shah, Neil P., Frett, Brendan, Li, Hong-yu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829162/
https://ncbi.nlm.nih.gov/pubmed/29487300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21839-3
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