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Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold

A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE.

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Dettagli Bibliografici
Autori principali: He, Guijia, Dou, Dengfeng, Wei, Liuqing, Alliston, Kevin R., Groutas, William C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918731/
https://ncbi.nlm.nih.gov/pubmed/20638756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2010.06.028
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