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Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold
A series of compounds based on the N-amino-4-imidazolidinone scaffold was synthesized and screened against human neutrophil elastase (HNE). These studies lead to the identification of a selective, low micromolar reversible competitive inhibitor of HNE.
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2918731/ https://ncbi.nlm.nih.gov/pubmed/20638756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2010.06.028 |
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