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Inactivation of Human Neutrophil Elastase by 1, 2, 5 – Thiadiazolidin-3-one 1, 1 Dioxide-based Sulfonamides

The interaction of a series of 1, 2, 5 –thiadiazolidin-3-one 1, 1 dioxide-based sulfonamides with neutrophil-derived serine proteases was investigated. The nature of the amino acid component, believed to be oriented toward the S′ subsites, had a profound effect on enzyme selectivity. This series of...

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Detalhes bibliográficos
Main Authors: Li, Yi, Yang, Qingliang, Dou, Dengfeng, Alliston, Kevin R., Groutas, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267890/
https://ncbi.nlm.nih.gov/pubmed/17976994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.10.041
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