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Effects of Structure on Inhibitory Activity in a Series of Mechanism-Based Inhibitors of Human Neutrophil Elastase
A structurally-diverse series of carboxylate derivatives based on the 1, 2, 5-thiadiazolidin-one 1, 1 dioxide scaffold were synthesized and used to probe the S’ subsites of human neutrophil elastase (HNE) and neutrophil proteinase 3 (Pr 3). Several compounds are potent inhibitors of HNE but devoid o...
Tallennettuna:
| Päätekijät: | , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2934896/ https://ncbi.nlm.nih.gov/pubmed/20728366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.07.071 |
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