Effects of Structure on Inhibitory Activity in a Series of Mechanism-Based Inhibitors of Human Neutrophil Elastase

A structurally-diverse series of carboxylate derivatives based on the 1, 2, 5-thiadiazolidin-one 1, 1 dioxide scaffold were synthesized and used to probe the S’ subsites of human neutrophil elastase (HNE) and neutrophil proteinase 3 (Pr 3). Several compounds are potent inhibitors of HNE but devoid o...

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Hlavní autoři: Dou, Dengfeng, He, Guijia, Kuang, Rongze, Fu, Qingfong, Venkataraman, Radhika, Groutas, William C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934896/
https://ncbi.nlm.nih.gov/pubmed/20728366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.07.071
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