Cyclosulfamide-based Derivatives as Inhibitors of Noroviruses

An optimization campaign focused on improving pharmacological activity and physicochemical properties of a recently-identified class of cyclosulfamide-based norovirus inhibitors has been carried out. Dimeric compound 4 was found to be a ~ 10-fold more potent norovirus inhibitor (ED(50) 0.4 μM) compa...

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Bibliographic Details
Main Authors:	Dou, Dengfeng, Mandadapu, Sivakoteswara R., Alliston, Kevin R., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.
Format:	Artigo
Language:	Inglês
Published:	2011
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3259182/ https://ncbi.nlm.nih.gov/pubmed/22063754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.10.019
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Cyclosulfamide-based Derivatives as Inhibitors of Noroviruses

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