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Cyclosulfamide-based Derivatives as Inhibitors of Noroviruses
An optimization campaign focused on improving pharmacological activity and physicochemical properties of a recently-identified class of cyclosulfamide-based norovirus inhibitors has been carried out. Dimeric compound 4 was found to be a ~ 10-fold more potent norovirus inhibitor (ED(50) 0.4 μM) compa...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259182/ https://ncbi.nlm.nih.gov/pubmed/22063754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.10.019 |
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